Detalhe da pesquisa
1.
Interactions of hydrolyzed ß-lactams with the L1 metallo-ß-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
J Biol Chem
; 299(5): 104606, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36924941
2.
Structural role of K224 in taniborbactam inhibition of NDM-1.
Antimicrob Agents Chemother
; 68(2): e0133223, 2024 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-38174924
3.
Deciphering the Coevolutionary Dynamics of L2 ß-Lactamases via Deep Learning.
J Chem Inf Model
; 2024 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-38687957
4.
Examining the activity of cefepime-taniborbactam against Burkholderia cepacia complex and Burkholderia gladioli isolated from cystic fibrosis patients in the United States.
Antimicrob Agents Chemother
; 67(11): e0049823, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37768313
5.
Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M ß-Lactamases: Biochemical and Structural Analyses.
Antimicrob Agents Chemother
; 67(1): e0093022, 2023 01 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36602311
6.
Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas-derived cephalosporinase.
Antimicrob Agents Chemother
; 67(11): e0079123, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37850746
7.
Treatment approaches for severe Stenotrophomonas maltophilia infections.
Curr Opin Infect Dis
; 36(6): 572-584, 2023 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37846568
8.
Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed blaPDC in a Hollow-Fiber Infection Model.
Antimicrob Agents Chemother
; 65(6)2021 05 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33782013
9.
The Reaction Mechanism of Metallo-ß-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30348667
10.
Cross-class metallo-ß-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Proc Natl Acad Sci U S A
; 113(26): E3745-54, 2016 06 28.
Artigo
Inglês
| MEDLINE | ID: mdl-27303030
11.
Exploring the Landscape of Diazabicyclooctane (DBO) Inhibition: Avibactam Inactivation of PER-2 ß-Lactamase.
Antimicrob Agents Chemother
; 61(6)2017 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28348157
12.
Avibactam Restores the Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia to Aztreonam.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28784669
13.
Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient.
Antimicrob Agents Chemother
; 60(9): 5130-4, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27551008
14.
Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases.
Biochemistry
; 54(20): 3183-96, 2015 May 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25915520
15.
Genetic basis for in vivo daptomycin resistance in enterococci.
N Engl J Med
; 365(10): 892-900, 2011 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-21899450
16.
14-Year Epidemiologic study of Pseudomonas aeruginosa bloodstream infection incidence and resistance in the Veterans Health Administration system, 2009-2022.
JAC Antimicrob Resist
; 6(2): dlae031, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38449517
17.
Rational Design of Benzobisheterocycle Metallo-ß-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
J Med Chem
; 67(5): 3795-3812, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38373290
18.
Association of COVID-19 coinfection with increased mortality among patients with Pseudomonas aeruginosa bloodstream infection in the Veterans Health Administration system.
Antimicrob Steward Healthc Epidemiol
; 3(1): e237, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-38156202
19.
Gating interactions steer loop conformational changes in the active site of the L1 metallo-ß-lactamase.
Elife
; 122023 02 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36826989
20.
Correction: 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-ß-lactamases.
Chem Sci
; 14(34): 9226, 2023 Aug 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37655038